Interleukin-12p40 overexpression promotes interleukin-12p70 and interleukin-23 formation but does not affect bacille Calmette–Guérin and Mycobacterium tuberculosis clearance
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منابع مشابه
Interleukin-8 but Not Interleukin-6 Variant May Affect Susceptibility to Brucellosis
Background: Increased levels of interleukin-8 (IL-8) and interleukin-6 (IL-6) in acute human brucellosis have been reported. Previous studies have shown that the production and level of IL-6 and IL-8 cytokines are associated with the polymorphism of the encoding genes. Objective: To investigate the probable association between IL-6 (-174 C/G) and IL-8 (-251 A/T) gene polymorphisms and susceptib...
متن کاملinterleukin-8 but not interleukin-6 variant may affect susceptibility to brucellosis
background: increased levels of interleukin-8 (il-8) and interleukin-6 (il-6) in acute human brucellosis have been reported. previous studies have shown that the production and level of il-6 and il-8 cytokines are associated with the polymorphism of the encoding genes. objective: to investigate the probable association between il-6 (-174 c/g) and il-8 (-251 a/t) gene polymorphisms and susceptib...
متن کاملEvaluation of Interleukin17and Interleukin 23 expression in patients with active and latent tuberculosis infection
Objective(s): Tuberculosis is one of the most important infectious diseases with high mortality rates worldwide, especially in developing countries. Interleukin17 (IL-17) is an important acquired immunity cytokine, which is mainly produced by CD4+TH17 cells. It can recruit neutrophils and macrophages to the infected site in the lungs. IL-23 is one of the most important inducers of IL-17. In the...
متن کاملInterleukin-17A and interleukin-23 in morphea
INTRODUCTION Morphea is a disease included in the group of scleroderma type autoimmune diseases. Interleukin (IL)-17A may play a role at every stage of its pathogenesis. The study aimed at evaluation of IL-17A and IL-23 (as the main cytokine which is supposed to stimulate and maintain synthesis of IL-17) in pathogenesis of morphea. MATERIAL AND METHODS The studies were performed on 41 blood s...
متن کاملWrestlers’ immune cells produce higher interleukin-6 and lower interleukin-12 and interleukin-13 in response toin vitro mitogen activation
Objective(s):Although recent investigations have shown chronic inflammation and inflammation-associated diseases might be ameliorated by exercise; little is known about the relation between exercise training with anti/pro-inflammatory cytokines. Materials and Methods: This cross sectional study was conducted to compare interleukin-4 (IL-4), IL-6, IL-10, IL-12, IL-13, interferon gamma (IFN-γ) le...
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ژورنال
عنوان ژورنال: Immunology
سال: 2007
ISSN: 0019-2805,1365-2567
DOI: 10.1111/j.1365-2567.2007.02646.x